Advertisement

Sleep Aid Comparison

What the popular over-the-counter sleep aids actually do, ranked by how strong the evidence is. Filter by your specific issue to see what's worth trying first.

What are you trying to fix?

CBT-I (cognitive behavioural therapy for insomnia)

Strong evidence

Trains your brain to associate the bed with sleep through stimulus control, sleep restriction, and cognitive reframing. The American College of Physicians' first-line recommendation.

Typical dose
6–8 sessions with a therapist or app
Onset
2–4 weeks for full effect
Best for
Chronic insomnia (>3 nights/week for >3 months)
Watch out for
Requires effort and consistency. The first two weeks of sleep restriction can be tough.

Melatonin

Moderate

A hormone your pineal gland releases as evening falls. Supplements signal your circadian system that it's time to wind down — useful for shifting the clock, not for sedation.

Typical dose
0.3–1 mg, 30–60 min before bed (most over-the-counter doses are 5-10× higher than needed)
Onset
30–60 minutes
Best for
Jet lag, shift work, delayed sleep phase
Watch out for
Larger doses can cause vivid dreams and grogginess. Not a sleeping pill — useless if you're not chronotype-shifted.

Magnesium (glycinate or threonate)

Moderate

Acts on GABA receptors and helps muscles relax. Best in chelated forms — citrate is a laxative, oxide barely absorbs.

Typical dose
200–400 mg, 30–60 min before bed
Onset
30–90 minutes
Best for
Stress, restless legs, muscle tension at bedtime
Watch out for
Citrate form will cause diarrhoea at the doses that help sleep. Avoid if you have kidney disease.

L-theanine

Moderate

An amino acid from tea leaves that promotes alpha brain waves — relaxation without sedation. Works particularly well paired with low-dose caffeine for daytime calm.

Typical dose
100–400 mg, 30–60 min before bed
Onset
30–45 minutes
Best for
Racing-mind insomnia, pre-bed anxiety
Watch out for
Effects are subtle — not a knockout. Some users report no effect at all.

Glycine

Weak / mixed

An amino acid that lowers core body temperature slightly, mimicking the temperature drop that naturally cues sleep. Small RCTs show improved subjective sleep quality.

Typical dose
3 g, 30–60 min before bed
Onset
30–60 minutes
Best for
Difficulty staying asleep, especially in warm rooms
Watch out for
Evidence base is small and mostly Japanese. Effects are modest.

Valerian root

Weak / mixed

A traditional herb thought to modulate GABA, though the mechanism is still unclear. Several RCTs but with mixed results.

Typical dose
300–600 mg, 30–60 min before bed
Onset
30–60 minutes
Best for
Mild occasional insomnia
Watch out for
Distinctive smell. Can cause vivid dreams and morning grogginess in some people. Avoid driving the next morning until you know how you respond.

Chamomile (tea or extract)

Weak / mixed

Contains apigenin, which binds weakly to benzodiazepine receptors. The ritual of warm tea is probably half the effect — and that's fine.

Typical dose
1–2 cups of strong tea, or 200–400 mg standardised extract
Onset
20–45 minutes
Best for
Mild stress, building a wind-down ritual
Watch out for
Pollen allergies — chamomile is in the ragweed family. Rare but real allergic reactions.

Diphenhydramine / doxylamine (OTC sleep aids)

Weak / mixed

First-generation antihistamines that cross the blood-brain barrier and cause sedation as a side effect. Sold under brand names like ZzzQuil, Unisom, Nytol.

Typical dose
Diphenhydramine 25–50 mg, doxylamine 12.5–25 mg, 30 min before bed
Onset
20–30 minutes
Best for
Single bad night, occasional use only
Watch out for
Tolerance builds fast. Morning grogginess is common. Linked to long-term cognitive risk in older adults. Not for nightly use.
Advertisement 728x90
Advertisement